Signaling Pathways in Cardiac Myocyte Apoptosis
نویسندگان
چکیده
منابع مشابه
Signaling Pathways in Cardiac Myocyte Apoptosis
Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly regulated process, pharmacological intervention of apoptosis pathways may represent a promising therapeutic strategy for a number of cardiovascular diseases and disorders including myocardial infarction, ischemia/reperfusio...
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Much diseased human myocardial tissue is fibrotic and stiff, which increases the work that the ventricular myocytes must perform to maintain cardiac output. The hypothesis tested is that the increased load due to greater stiffness of the substrata drives sarcomere assembly of cells, thus strengthening them. Neonatal rat ventricular myocytes (NRVM) were cultured on polyacrylamide or polydimethyl...
متن کاملCardiac myocyte apoptosis.
Apoptosis, or programmed cell death, is an energy dependent process that effects the controlled removal of a cell. The process is activated during tissue development, such that unneeded structures may be removed and tissues can be shaped and sculpted. It is also activated in response to cellular injury and results in the removal of the injured cell without damaging surrounding tissue. The proce...
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Sympathetic nerve activity increases in the heart during cardiac failure. Here, we hypothesized that 1 integrins play a protective role in chronic -adrenergic receptor–stimulated cardiac myocyte apoptosis and heart failure. L-isoproterenol (iso; 400 g/kg per hour) was infused in a group of wild-type (WT) and 1 integrin heterozygous knockout (hKO) mice. Left ventricular structural and functional...
متن کاملImportant role of energy-dependent mitochondrial pathways in cultured rat cardiac myocyte apoptosis.
Recent studies have suggested that apoptosis and necrosis share common features in their signaling pathway and that apoptosis requires intracellular ATP for its mitochondrial/apoptotic protease-activating factor-1 suicide cascade. The present study was, therefore, designed to examine the role of intracellular energy levels in determining the form of cell death in cardiac myocytes. Neonatal rat ...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2016
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2016/9583268